Bruce McLaren won the United States Grand Prix 1959 at Sebring International Raceway on 12 December 1959, starting from P10 on the grid. Maurice Trintignant finished second for Cooper-Climax, with Tony Brooks completing the podium for Ferrari.
| Pos | Grid | Driver | Team | Laps | Time / Status | Pts | FL |
|---|---|---|---|---|---|---|---|
| 1 | 10 | Bruce McLarenMCL | Cooper-Climax | 42 | 2:12:35.7 | 8 | |
| 2 | 5 | Maurice TrintignantTRI | Cooper-Climax | 42 | +0.6 | 7 | |
| 3 | 4 | Tony BrooksBRO | Ferrari | 42 | +3:00.9 | 4 | |
| 4 | 2 | Jack BrabhamBRA | Cooper-Climax | 42 | +4:57.3 | 3 | |
| 5 | 9 | Innes IrelandIRE | Team Lotus | 39 | +3 Laps | 2 | |
| 6 | 6 | Wolfgang von TripsVON | Ferrari | 38 | Engine | 0 | |
| 7 | 16 | Harry BlanchardBLA | Porsche | 38 | +4 Laps | 0 | |
| R | 11 | Cliff AllisonALL | Ferrari | 23 | Transmission | 0 | |
| R | 11 | Roy SalvadoriSAL | Cooper-Maserati | 23 | Transmission | 0 | |
| R | 19 | Rodger WardWAR | Kurtis Kraft | 20 | Clutch | 0 | |
| R | 14 | Alessandro de TomasoDET | Cooper-OSCA | 13 | Brakes | 0 | |
| R | 8 | Phil HillHIL | Ferrari | 8 | Clutch | 0 | |
| R | 17 | Fritz d'OreyDOR | Tec-Mec | 6 | Oil leak | 0 | |
| R | 1 | Stirling MossMOS | Cooper-Climax | 5 | Transmission | 0 | |
| R | 3 | Harry SchellSCH | Cooper-Climax | 5 | Clutch | 0 | |
| R | 15 | George ConstantineCON | Cooper-Borgward | 5 | Overheating | 0 | |
| R | 12 | Alan StaceySTA | Team Lotus | 2 | Clutch | 0 | |
| R | 13 | Bob SaidSAI | Connaught | 0 | Accident | 0 | |
| W | 0 | Phil CadeCAD | Maserati | 0 | Withdrew | 0 |